承担科研项目

1. 中韩国际合作交流项目， China-Korea Exchange Program, “GPCR protein structure and dynamics study using X-ray free electron lasers” 1181101028, 2018-7-1 to 2020-6-30. PI, NSFC-NRF joint grant.

2. “应用时间分辨串行晶体衍射和分子动力学模拟方法研究视紫质蛋白氯离子输运的分子机理”，Time-resolved Serial crystallography and molecular dynamics simulation studies of Cl- ion pumping rhodopsin. NSFC 3197110508， 2020-01-01 to 2023-12-31. PI, general NSFC.

3. National Natural Science Foundation of China (NSFC), General Project, Application of X-ray Free-Electron-Laser in biological particle structure determination and Method Development, 2015-2019, PI, project ID 11575021

4. National Natural Science Foundation of China (NSFC), NSAF-Joint Project, Multiscale modeling method and platform for self-organizing systems, 2014-2018, Co-I, project ID U1430237.

代表性学术论文

[1]Haiguang Liu, BK Poon, DK Saldin, JCH Spence, PH Zwart. Towards 3D reconstructions of non-crystalline bioparticles with X-ray lasers. Acta. Cryst. A69. 365-373 (2013)

[2]Ji-Hye Yun, Xuanxuan Li, Jianing Yue, Jae-Hyun Park, Zeyu Jin, Chufeng Li, Hao Hu, Yingchen Shi, Suraj Pandey, Sergio Carbajo, Sébastien Boutet, Mark S Hunter, Mengning Liang, Raymond G Sierra, Thomas J Lane, Liang Zhou, Uwe Weierstall, Nadia A Zatsepin, Mio Ohki, Jeremy RH Tame, Sam-Yong Park, John CH Spence, Wenkai Zhang, Marius Schmidt*, Weontae Lee*, Haiguang Liu* Early-stage dynamics of chloride ion–pumping rhodopsin revealed by a femtosecond X-ray laser. PNAS (2021) 118(13) 

[3]Pei Li, Huaqiang Cheng, Vikash Kumar, Cecylia Severin Lupala, Xuanxuan Li, Yingchen Shi, Chongjun Ma, Keehyoung Joo, Jooyoung Lee, Haiguang Liu*, Yan-Wen Tan*. Direct experimental observation of blue-light-induced conformational change and intermolecular interactions of cryptochrome. Communications Biology. (2022) 5(1) 1103

[4]Shuxin Zheng, Jiyan He, Chang Liu, Yu Shi, Ziheng Lu, Weitao Feng, Fusong Ju, Jiaxi Wang, Jianwei Zhu, Yaosen Min, He Zhang, Shidi Tang, Hongxia Hao, Peiran Jin, Chi Chen, Frank Noé, Haiguang Liu, Tie-Yan Liu. Towards predicting equilibrium distributions for molecular systems with deep learning. Nature Machine Intelligence 6, 558–567 (2024).

[5]Wu, K., Xia, Y., Deng, P. et al. TamGen: drug design with target-aware molecule generation through a chemical language model. Nat Commun 15, 9360 (2024)

主要成就与荣誉

国家人才计划（青年）2013

学术兼职

北京师范大学 兼职教授

行业贡献

期刊编辑：AI for Science 副编辑； Frontier in Molecular Biophysics 副编辑

期刊审稿人：Science, Nature communications, Nature machine intelligence, Nature Communications Biology, IUCrJ, Acta. Crystal A, Acta Crystal D, Acta Crystal F, Journal of Structural Biology, Advances in condensed matter physics, Philosophical Transactions B, PLOS One, Journal of Structural and Functional Genomics, International Journal of Modern Physics C