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北京中关村学院导师
北京中关村学院AI for Science 研究员，2025年毕业于北京理工大学。主要工作致力于合成生物学相关的调控元件设计、底盘细胞改造、基因编辑方法开发等工作；利用语言模型实现了调控元件智能设计，并将人工调控元件应用于底盘细胞开发。尤其是近年来，发展专门PromoGen系列DNA语言模型；并将通用语言模型应用于合成生物学智能体，开发了CRISPR-copilot。在Nucleic Acids Research, Cell Reports, Chemical Engineering Journal, Bioresource Technology等国际主流学术刊物上发表多篇论文。
I. 研究方向
DNA调控元件设计：利用语言模型进行启动子、增强子等元件的智能设计；构建人工调控元件库并验证其功能性。
基因编辑方法开发：改进CRISPR系统的靶向效率和范围；构建智能辅助设计工具CRISPR-copilot，提升编辑设计的准确性。
语言模型与生物系统深度融合：探索语言模型在序列设计、实验规划、知识推理等方面的应用；推进合成生物学的智能化、自动化研究范式。
II. 教育经历
2021-2025 北京理工大学 理学博士
2018-2021 中科院微生物研究所-南京工业大学 理学硕士
2014-2018 南京工业大学 工学学士
III. 代表性学术论文
[1] Yan Xia et al. Species-specific design of artificial promoters by transfer-learning based generative deep-learning model, Nucleic Acids Research.
[2] Yan Xia et al. Design nonrepetitive and diverse activity single-guide RNA by deep learning, 2024. biorxiv.
[3] Yan Xia† et al. Large language model generates regulatory sequences across diverse prokaryotic species, 2024. biorxiv.
[4] Zeyu liang, Chaoyong huang, Yan Xia et al. Identification of functional sgRNA mutants lacking canonical secondary structure using high-throughput FACS screening,2024. Cell Reports.
[5] Yan Xia et al. Chromosome segment scanning for gain- or loss-of-function screening (CHASING) and its application in metabolic engineering, 2025. iScience.
[6] Zeyu Liang†, Zhaojin Ye†, Yan Xia† et al. Low-cost and rapid construction of green energy overproducers based on the CRISPR system, 2025. Chemical Engineering Journal.
[7] Yingjie Guo, Yan Xia et al. Plasmid-stabilizing strains for antibiotic-free chemical fermentation. ACS Synthetic Biology.
[8] Yan Xia† et al. The construction of a PAM-less base editing toolbox in Bacillus subtilisand its application in metabolic engineering, Chemical Engineering Journal.
[9] Jianbo Yang, Yan Xia et al. Screening signal peptides from Bacillus thuringiensis secretome for heterologous protein secretion, Applied Microbiology and Biotechnology.
[10] Shuxian Wang, Jiayu Fang, Meiyu Wang, Sijie Yu, Yan Xia et al. Rewiring the methanol assimilation pathway in the methylotrophic yeast Pichia pastorisfor high-level production of erythritol, Bioresource Technology.
[11] Jinyuan Sun†, Yan Xia† et al. Whole-genome sequencing and bioinformatics analysis of Apiotrichum mycotoxinivorans: predicting putative zearalenone-degradation enzymes, 2020. Frontiers in Microbiology.
[12] Yan Xia et al. Strategies for enhancing eicosapentaenoic acid production: From fermentation to metabolic engineering, 2020. Algal Research.
IV. 主要成就与荣誉
国家奖学金
北京市优秀毕业生
北京理工大学优秀毕业生
北京理工大学优秀博士学位论文